Research Progress on Traditional Chinese Medicine Targeting and Regulating Mitochondrial Dysfunction to Intervene in Diabetic Nephropathy
DOI:
https://doi.org/10.62767/jecacm604.1225Keywords:
Traditional Chinese medicine, mitochondrial dysfunction, diabetic nephropathyAbstract
Diabetic nephropathy (DN) is the most common cause of adult nephrotic syndrome and of global renal failure. In traditional Chinese medicine (TCM), DN belongs to the category of “renal wasting thirst disorders”. As early as the Han dynasty, historical records documented the efficacy of TCM in reducing albuminuria of DN patients. The chronic hyperglycemia in diabetic patients leads to progressive damage to renal microvessel (especially glomerulus), ultimately disrupting renal structure and function. The changes of mitochondrial morphology and quantification precede the onset of diabetic albuminuria and renal histological changes and development. This study reviews the latest research on TCM targeting and regulating mitochondrial dysfunction to ameliorate DN, with the aim of providing prophylaxis and treatment methods of DN.
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The data presented in this study are available on request from the corresponding author.
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