Research Progress of Yihuang Decoction and Prediction Analysis on Quality Markers
DOI:
https://doi.org/10.62767/jecacm501.7012Keywords:
Yihuang Decoction, chemical constituents, pharmacological effect, clinical application, Q-markerAbstract
Background: Yihuang Decoction, a classical prescription found in Fu Qingzhu's Obstetrics and Gynecology, is formulated with fried Dioscoreae Rhizoma, fried Euryales Semen, wine-fried Plantaginis Semen, salt-fried Phellodendri Chinensis Cortex and Ginkgo Semen. Quality marker (Q-marker) plays a crucial role in promoting the standardization of the quality of traditional Chinese medicine (TCM). Hence, this study aimed to predict and analyze the Q-marker of Yihuang Decoction based on TCM Q-marker theory. Methods: A comprehensive review of relevant literature and the TCMSP database was conducted to investigate the chemical constituents, pharmacological effects, and clinical applications of Yihuang Decoction. Furthermore, the study predicted the Q-marker of Yihuang Decoction by considering its effectiveness, specificity, measurability, transmissibility and traceability, and compatibility, as per the concept of Chinese medicine Q-marker. Results: Yihuang Decoction exhibits pharmacological effects such as anti-inflammation and immune modulation, anti-bacteria and anti-virus properties. Clinically, it is mostly used to treat inflammation of the female reproductive system, including vaginitis, cervicitis and pelvic inflammation. According to analysis and prediction, it was suggested that allantoin, diosgenin, gallic acid, α-tocopherol, bilobalide, ginkgolide A, ginkgolide B, berberine, phellodendrine, magnoflorine, geniposidic acid and verbascoside could serve as Q-markers of Yihuang Decoction. Conclusion: This review establishes a foundation for the research and development of Yihuang Decoction, and providing a crucial scientific reference for ensuring its comprehensive quality control and enhancing evaluation standards.
References
Xia MY, Zhang X, Wang Y, et al. Research progress on processing methods, chemical components, pharmacological activities, and clinical applications of ginkgo. Chinese Pharmacy 2020; 31(01): 123-128.
Li HL, Li QT, Liu HL, et al. Establishment of HPLC characteristic chromatograms and study on quantity transfer of reference substances in the classic formula Yihuang Tang. Journal of Nanjing University of Traditional Chinese Medicine 2022; 38(07): 621-630.
Fu S. Fu qingzhu 's obstetrics and gynecologyis. China press of traditional chinese medicine: Beijing, China, 2019.
Li HL, Li QT, Liu HL, et al. Establishment of HPLC characteristic chromatogram and study on quality value transmitting of substance benchmarks of Yihuang decoction. Journal of Nanjing University of Traditional Chinese Medicine 2022; 38(07): 621-630.
Wang Y, Yan J. Clinical analysis of modified Yihuang Tang in the treatment of urinary tract infections. Xinjiang Traditional Chinese Medicine 2001: 20-21.
Lin L, Wang MH, Huang Y, et al. Observation on the curative effect of Yihuang Decoction on cervical high-risk human papillomavirus infection. Strait Pharmaceutical Journal 2021; 33(03): 117-119.
Liu CX, Chen SL, Xiao XH, et al. A new concept on quality marker of chinese materia medica: quality control for chinese medicinal products. Chinese Traditional and Herbal Drugs 2016; 47(9): 1443-1457.
Zhang TJ, Bai G, Liu CX. The concept, core theory and research methods of chinese medicine quality markers. Acta Pharmaceutica Sinica 2019; 54(2): 187-196.
Pan JZ, Meng QL, Cui WY, et al. Advances in studies on functional components and pharmacological effects of dioscorea opposita thunb. Science and Technology of Food Industry 2023; 44(01): 420-428.
Xu CP, Sun YY, Bai JF, et al. Study on the extraction, sulfation modification and antioxidant activity of yam polysaccharides. Journal of Henan University of Technology of China (Natural Science Edition) 2019; 40(03): 50-55.
Liu LJ, Wang LY, Sun YT, et al. Quality analysis and comparison of pharmacological active components of yams in different areas of northeast China. Journal of Yunnan Agricultural University (Natural Science) 2021; 36(2): 308-313.
Xue Z, Cao Z, Jin M, et al. New steroid saponins from dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect. Food & Function 2021; 12(18): 8314-8325.
Ma R, Wang LL, Chen SQ. Analysis of commodity specifications and quality characteristics of Dioscoreae Rhizoma. Chinese Traditional Patent Medicine 2020; 42(7): 1936-1942.
Guo ZH. Studies on the component characteristics and antioxidant properties of gorgon nut polyphenols. Yangzhou University: Yangzhou, China, 2018.
Wang Y. Chemical constituents and biological activity of euryale ferox salisb. Shandong University: Jinan, China, 2019.
Deng QT, Qi Y, Wang QH. Processing evolution and modern research progress of euryale ferox. China Pharmacy 2022; 33(15): 1911-1915.
Zhang QQ, Li HF, Zhang XL, et al. Simultaneous determination of four terpene lactones in Ginkgo Semen from different growing areas by HPLC-ELSD. Chinese Traditional Patent Medicine 2016; 38(1): 133-136.
Shan SJ. Investigation on the chemical constituents of medicine-food ginkgo seed and bitter leaf. Shenyang Pharmaceutical University: Shenyang, China, 2018.
Cui X, Chen R, Zhang P, et al. Characterization of Plantaginis Semen by UPLC-O-TOF MSE. Guangzhou Chemical Industry 2017; 45(16): 105-107.
Shi M, Ren BN, Qiu ZH, et al. Rapid identification of the components in Phellodendri Chinensis Cortex based on UPLC-O-TOF-MS. Chinese Journal of Hospital Pharmacy 2022; 42(21): 2225-2229.
Feng Y, Guo L, Chang YQ, et al. Research on difference of phellodendron amurense and phellodendron chinense based on fingerprint and multicomponent content determination. Chinese Traditional and Herbal Drugs 2022; 53(16): 5179-5184.
Wang LT, Li YL, Xu G, et al. Analysis of the chemical constituents in different solvent extracts of Plantaginis Semen by UPLC-Q-Exactive-Orbitrap mass spectrometry. China Pharmacist 2022; 25(08): 1341-1347.
Sun YJ, Huo ZP, Wang Y, et al. Analysis of chemical composition variations in Plantaginis Semen at different frying time based on UPLC-Q-TOF/MSE. Chinese Journal of Experimental Traditional Medical Formulae 2022; 28(4): 146-153.
Gu CM, Wang ZH, Zheng SH, et al. Analysis on chemical compositions of crude and alt-processed plantago asiatica L. by UPLC-Q-TOF/MS. World Science and Technology-Modernization of Traditional Chinese Medicine and Materia Medica 2016; 18(01): 77-81.
Fan YH. Effects of Yihuang Decoction combined with recombinant human interferon in treatmentof patients with cervical high-risk human papillomavirus infection. Medical Journal of Chinese People's Health 2022; 34(05): 101-103.
Lin L,You PC,Wu DM, et al. Effect of Yihuang Decoction on vaginal microecology and local immunity with cervical HR-HPV ( hign-risk Human Papilloma Virus) infection. Strait Pharmaceutical Journal 2021; 33(10): 93-95.
Kuang XH, Jiang WW. Observation on the curative effect of Yihuang Decoction clysis in the treatment of damp-heat-toxin pelvic inflammation and its influence on recurrence. Journal of New Chinese Medicine 2016; 48(04): 126-128.
Li JD, Ying TG. Observation on the curative effect of Yihuang Decoction clysis combined with Western medicine in the treatment of damp-heat-toxin pelvic inflammation. Journal of New Chinese Medicine 2015; 47(03): 167-169.
Guang H, Qin QR. A theoretical exploration of compound Yihuang Decoction in treating bacterial vaginosis. Clinical Journal of Chinese Medicine 2015; 7(33): 78-79.
Xu ZH. Clinical Observation on modified Yihuang Decoction combined with Baofukang suppository in the treatment of Senile Vaginitis. Guangming Journal of Chinese Medicine 2019; 34(7): 984-986.
Liu XQ, Li MR, Wang JY. Clinical observation of modified Yihuang Decoction combined with Baofukang in the treatment of senile vaginitis. Clinical Research and Practice 2017; 2(35): 109-110.
Chen YX. Observation on the curative effect of combined use of chinese and western medicine on senile vaginitis. Journal of Practical Traditional Chinese Medicine 2021; 37(6): 1024-1025.
Xing SP. Analysis on the curative effect and value of modified Yihuang Decoction combined with Baofukang in treating senile vaginitis. Guangming Journal of Chinese Medicine 2019; 34(3): 349-351.
Wu XL. Effect of Oral Administration of Yihuang Decoction and self-made qingdu prescription on viral load, TNF-α and hs-CRP Level in patients with cervical HPV infection. Guangming Journal of Chinese Medicine 2021; 36(1): 84-86.
Duan Q, Liu T, Yuan P, et al. Antiviral effect of chinese herbal prescription JieZe-1 on adhesion and penetration of VK2/E6E7 with herpes simplex viruses type 2. Journal of Ethnopharmacology 2020; 249: 112405.
Li S, Xu J, Jin SF. Effect of Yihuang Decoction combined with chitosan membrane in the treatment of cervical HPV infection. Guangming Journal of Chinese Medicine 2017; 32(23): 3454-3457.
Wen J, Yang JH. Literature studying on clinical application of Yihuang Decoction. Guangming Journal of Chinese Medicine 2012; 27(9): 1740-1742.
Qiu F, Huang KJ. Analysis on the curative effect of modified Yihuang Decoction combined with Baofukang in treating Senile Vaginitis. Health Guide 2018; (7): 295.
Bi LJ. Analysis on the treatment of senile vaginitis by modifiled Yihuang Decoction. Shanxi Journal of Traditional Chinese Medicine 2022; 38(5): 69-70.
Wang XX, Yu LN, Tang RD. Clinical observation of Yihuang Decoction combined with western medicine in treating vaginitis. Journal of New Chinese Medicine 2016; 48(2): 152-154.
Yue Q. Clinical observation on modified Yihuang Decoction combined with metronidazole vaginal suppository in the treatment of recurrent bacterial vaginosis with damp-heat and spleen deficiency. Journal of Sichuan of Traditional Chinese Medicine 2021; 39(1): 151-153.
Hao FR. Treatment for 40 cases of acute pelvic inflammation with integrative medicine. Western Journal of Traditional Chinese Medicine 2013; (9): 90-91.
Chen F. Observation on the effect of Yihuang Decoction combined with antibiotics on chronic pelvic inflammation. Chinese Journal of Rural Medicine and Pharmacy 2012; 19(3): 42.
Liu SM, Yuan JC, Du XH, et al. Treatment for 120 cases of cervical erosion with modified Yihuang Decoction. Chinese Medicine Modern Distance Education of China 2011; 9(18): 39-40.
Tian LX, Xu LW, Luo XJ. Evaluation of the curative effect of Yihuang Decoction in the treatment of recurrent vulvovaginal candidiasis. Journal of Medical Forum 2017; 38(8): 163-164.
Tan TH. Clinical observation of 50 cases of female genital tract mycoplasma infection treated by integrated chinese and western medicine. Jiangsu Journal of Traditional Chinese Medicine 2017; 49(1): 37-39.
Liu D. Treatment of 30 cases of ovulation hemorrhage with modified Yihuang Decoction. Lishizhen Medicine and Materia Medica Research 2006; 17(8): 1531.
Xin LY, Wang TT, Tao HJ. Clinical Study on Yihuang Decoction combined with recombinant interferon for cervical high-risk human papilloma virus infection. Journal of New Chinese Medicine 2023; 55(03): 155-158.
Zhen JF. A clinical observation on the curative effect of YiHuang Decoction combined with recombinant human interferon on cervical HR-HPV infection and its impact on virval load. Fujian University of Traditional Chinese Medicine: Fuzhou, China, 2013.
Ru JL, Li P, Wang JN, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. Journal of Cheminformatics 2014; 6(1): 13.
Bi JY, Tian WW, Zhang Y, et al. Analysis on quality transmitting of substance benchmarks of Yihuangtang. Chinese Journal of Experimental Traditional Medical Formulae 2021; 27(16): 24-31.
Zhou J, Yu S, Wang B, et al. Chemical profiling and quantification of Yihuang Decoction by high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and a diode array detector. Journal of Pharmaceutical and Biomedical Analysis 2023; 224: 115199.
Gong XJ, Zhou X, Chen HG, et al. Study on quality standard of psammosilene tunicoides based on absorbed active components in rat plasma. China Journal of Chinese Materia Medica 2013; 38(13): 2151-2154.
Chang JH, Liu XG, Xue HF, et al. Determination of diosgenin in rat plasma by UPLC-MS/MS. Chinese Pharmaceutical Journal 2017; 52(17): 1536-1541.
Pan YY, Yu Y, Lai GX, et al. Analysis of primary metabolites of α-tocopherol in human urine by liquid chromatography-mass spectrometry. Acta Pharmaceutica Sinica 2008; 43(6): 634-639.
Zhu YP, Zhang WM, Wu K, et al. Study on pharmacokinetics and bioavailability of gallic acid in rats. Northwest Pharmaceutical Journal 2021; 36(3): 430-434.
Li KY. Study on tissue distribution, intestinal absorption and metabolomics of gallic acid. Wuhan University: Wuhan, China, 2019.
Peter Y. Assessment of the role of drug transporters in the pharmacokinetics and renal excretion of ginkoolides and bilobalide. Zhejiang University: Hangzhou, China, 2019.
Kang LX, Xu ZP, Liu Y, et al. Identification of prototype components and their metabolites in rat serum, urine and feces after oral administration of phellodendri amurensis cortex aqueous extract by UPLC-Orbitrap fusion lumos tribrid-MS. Chinese Journal of Experimental Traditional Medical Formulae 2021; 27(11): 139-146.
Xu Z. Pharmacokinetic study of the pharmacodynamic components group in the anemarrhenae rhizome and Phellodendri Chinensis Cortex in rats. Shanghai Normal University: Shanghai, China, 2017.
Tan Q. Analysis on selection of evaluation markers by absorbed components. Shaanxi University of Chinese Medicine: Xianyang, China, 2011.
Xiao XY, Feng G, Li W, et al. Tissue distribution of geniposidic acid in rats by UPLC-MS/MS. Guizhou Medical Journal 2021; 45(8): 1182-1185.
Bu M. Pharmacokinetic research of geniposidic acid in rats. Chinese Manipulation and Rehabilitation Medicine 2021; 12(16): 76-78.
Wen Y, Huo S, Zhang W, et al. Pharmacokinetics, biodistribution, excretion and plasma protein binding studies of acteoside in rats. Drug Research (Stuttgart) 2016; 66(3): 148-153.
Tang Q, Wang R, Yang DQ, et al. Study on TLC identification and allantoin content determination of soil fried Dioscoreae Rhizoma. Drug Evaluation 2022; 19(14): 853-857.
Lv H, Zhang QL, Sun XM. Determination of allantoin content in chinese yam herbs from differeni habitats. Journal of Harbin University of Commerce (Natural Sciences Edition) 2020; 36(1): 13-16.
Li CL, Wu XL, Zhu D, et al. Study on the diosgenin content of yam in different period. Ginseng Research 2014; 26(1): 33-35.
Li LL, Zhao HX. Determination of diosgenin in chinese yam from different habitats by HPLC. Shandong Journal of Traditional Chinese Medicine 2011; 30(2): 122-123.
Wang H, Wu QN, Wu CY, et al. Determination of different configuration of vitamin E in euryale semen by HPLC. Science and Technology of Food Industry 2014; 35(08): 74-78.
Bao K. Study on the quality evaluation and influencing factors of Euryales Semen from different origins. Nanjing University of Traditional Chinese Medicine: Nanjing, China, 2022.
Wang Q, He RX, Xu YD, et al. Study on the preparation process of the material standard of the classic "Yihuang Decoction". Journal of Liaoning University of Traditional Chinese Medicine 2021; 23(11): 43-48.
Qiu YY. In vitro metabolism and drug interaction of ginkgolides and bilobalide. Zhejiang University: Hangzhou, China, 2005.
Peng AH, Yang H, Yang L, et al. Content determination of berberine and phellodendrine in phellodendron chinese from different collection periods by RP-HPLC. West China Journal of Pharmaceutical Sciences 2006; 21(4): 377-379.
Tang YM, Ye M, Xiang L, et al. Determination of berberine hydrochloride, palmatine hydrochloride and jatrorrhizine hydrochloride in Plantaginis Semen chinensis by HPLC. West China Journal of Pharmaceutical Sciences 2006; 21(3): 265-267.
Fan SM, Yang YX, Zhang CL, et al. Changes of HPLC fingerprint and multi-index components of anemarrhenae rhizoma-phellodendri chinensis herb pair before and after salt-processing. Chinese Traditional Patent Medicine 2023; 45(3): 820-828.
Tian WW, Zhong LY, Zhang Q, et al. Optimum processing technology with wine and comparative study of different processed products of Plantaginis Semen. Tianjin Journal of Traditional Chinese Medicine 2020; 37(02): 220-226.
Li Y, Li W, Zhang XY, et al. Effects of the herbal pair shanyao and qianshi at different dosage ratios on spleen-deficiency mice ’s immune function. Journal of Beijing University of Traditional Chinese Medicine 2015; (8): 535-538.
Miyoshi N, Nagasawa T, Mabuchi R, et al. Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin. Cancer Prevention Research 2011; 4(6): 924-934.
Su Q, Dong J, Zhang D, et al. Protective effects of the bilobalide on retinal oxidative stress and inflammation in streptozotocin-induced diabetic rats. Applied Biochemistry and Biotechnology 2022; 194(12): 6407-6422.
Zhao JQ, Bao YZ, Han CH. Effects of bilobalide on TLR4/NFκB signaling pathway and Th1/Th2 cells in rats with sepsis induced acute lung injury. Medical Journal of West China 2021; 33(5): 655-659.
Wu F, Shi W, Zhou G, et al. Ginkgolide B functions as a determinant constituent of ginkgolides in alleviating lipopolysaccharide-induced lung injury. Biomedicine & Pharmacotherapy 2016; 81: 71-78.
Xue J, Zeng WM, Wang CF, et al. Separation and purification of polysaccharides from phellodendri amurensis cortex and effect on proliferation function of mice spleen lymphocyte. Chinese Journal of Experimental Traditional Medical Formulae 2015; 21(14): 44-48.
Xu MQ, Lu YW, Yi HM, et al. Study on the inhibitory effect of phellodendrine on LPS-induced microglia activation and its mechanism. Guiding Journal of Traditional Chinese Medicine and Pharmacy 2021; 27(07): 10-15.
Tang YF, Huang DF, Xie MY, et al. Effects of verbascoside and isoverbascoside on proliferation of dendritic cells. Chinese Pharmaceutical Journal 2008; 43(23): 1785-1787.
Pesce M, Franceschelli S, Ferrone A, et al. Verbascoside down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in the U937 cell line. Journal of Cellular and Molecular Medicine 2015; 19(7): 1548-1556.
Li F, Huang D, Nie S, et al. Polysaccharide from the seeds of plantago asiatica L. protect against lipopolysaccharide-induced liver injury. Journal of Medicinal Food 2019; 22(10): 1058-1066.
Xie XM, Fu ZH, Wu J, et al. Effects of polysaccharide from the seeds of plantago asiatica L. on immunological function of mice. Immunological Journal 2009; 25(02): 232-233.
Yu L, Zhang JT, Ma SX, et al. Optimization of polysaccharide extraction from yam and its antibiotic activity. Chinese Traditional Patent Medicine 2014; 36(6): 1194-1198.
Li XL, Liu J, Yan W, et al. Antioxidant and antimicrobial activities of the polysaccharides from euryale ferox. Food and Fermentation Industries 2014; 40(11): 104-108.
Xu ZH, Wang HJ, Luan ZX, et al. Identification of staphylococcus aureus in biofilm formation and inhibition of polysaccharide from ginkgo biloba sarcotesta on biofilm. Veterinary Science in China 2017; 47(12): 1602-1608.
Lu X, Zhou L, Xie KP, et al. Antibacterial activity and mechanism of gallic acid on staphylococcus aureus. Edible Fungi of China 2012; 31(4): 54-56,61.
Jing WH, Dong SJ, Luo XY, et al. Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacological Research 2021; 164: 105358.
Xia S, Ma LY, Xie MR. Antimicrobial activities of berberine agaist staphylococcus aureus in vitro. Journal of Clinical and Experimental Medicine 2022; 21(7): 673-678.
Mahata S, Bharti AC, Shukla S, et al. Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Molecular Cancer 2011; 10: 39.
Singh T, Chhokar A, Thakur K, et al. Targeting aberrant expression of STAT3 and AP-1 oncogenic transcription factors and HPV oncoproteins in cervical cancer by berberis aquifolium. Frontiers in Pharmacology 2021; 12: 757414.
Kim J H, Weeratunga P, Kim M S, et al. Inhibitory effects of an aqueous extract from Plantaginis Semen on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complementary and Alternative Medicine 2016; 16: 265.
Mou JF, Lin XZ, Su HL, et al. Anti-hepatitis B virus activity and hepatoprotective effect of des(rhamnosyl) verbascoside from Lindernia ruellioides in vitro. Phytotherapy Research 2021; 35(8): 4555-4566.
Fu YY, Jiang YL, Shan MiQ, et al. Study on characteristic chromatogram and determination of indicative components of salt-fried Phellodendri Chinensis Cortex and Yihuang Decoction. Chinese Traditional and Herbal Drugs 2020; 51(10): 2790-2797.
Luo J, Shen YX, Zhou N, et al. Content determination of diosgenin in paris polyphylla var. yunnanensis from 14 different habitats by HPLC. China Pharmacy 2015; (21): 2965-2967.
Zhang Y, Wang XY, Wang XF, et al. Determination of tocopherols in oil seeds by reversed phase high performance liquid chromatography. Food and Fermentation Industries 2022; 48(12): 243-248.
Pan C, Zhang L, Wang Y. Simultaneous determination of phellodendrine, magnoflorine, jatrorrhizine, palmatine hydrochloride and berberine hydrochloride in Ermiao Pill by HPLC. Chinese Journal of Biochemical Pharmaceutics 2012; 33(4): 361-364.
Chen QZ. HPLC determination of the content for six constituents before and after salt processing of Plantaginis Semen from different habitats. International Journal of Traditional Chinese Medicine 2021; 43(8): 784-788.
Published
Versions
- 2024-05-20 (2)
- 2024-02-20 (1)
Data Availability Statement
The analyzed data sets generated during the study are available from the corresponding author on reasonable request.Issue
Section
License
Copyright (c) 2024 The Author(s)
This work is licensed under a Creative Commons Attribution 4.0 International License.
