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Research Progress of Yihuang Decoction and Prediction Analysis on Quality Markers

Authors

  • Menggai Zhang School of Pharmacy, Health Science Center, Xi'an Jiaotong University, 710061, Xi'an, Shanxi, China Author
  • Xue Liu School of Pharmacy, Health Science Center, Xi'an Jiaotong University, 710061, Xi'an, Shanxi, China Author
  • Hehe Shi School of Pharmacy, Health Science Center, Xi'an Jiaotong University, 710061, Xi'an, Shanxi, China Author
  • Yinyue Xu School of Pharmacy, Health Science Center, Xi'an Jiaotong University, 710061, Xi'an, Shanxi, China Author
  • Longbiao Luo Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, 999078, Taipa Island, Macao, China Author
  • Lijin Yu Xinzhou Hospital of Traditional Chinese Medicine, 034099, Xinzhou, Shanxi, China Author
  • Yitao Wang Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, 999078, Taipa Island, Macao, China Author
  • Sicen Wang School of Pharmacy, Health Science Center, Xi'an Jiaotong University, 710061, Xi'an, Shanxi, China Author
  • Wanghui Jing Doctor, A.P., research direction: Study on effectiveness and controllability of traditional Chinese medicine Author

DOI:

https://doi.org/10.62767/jecacm501.7012

Keywords:

Yihuang Decoction, chemical constituents, pharmacological effect, clinical application, Q-marker

Abstract

Background Yihuang Decoction, a classical prescription found in Fu Qingzhu's Obstetrics and Gynecology, is formulated with fried Dioscoreae Rhizoma, fried Euryales Semen, wine-fried Plantaginis Semen, salt-fried Phellodendri Chinensis Cortex and Ginkgo Semen. Quality marker (Q-marker) plays a crucial role in promoting the standardization of the quality of traditional Chinese medicine (TCM). Hence, this study aimed to predict and analyze the Q-marker of Yihuang Decoction based on TCM Q-marker theory. Methods A comprehensive review of relevant literature and the TCMSP database was conducted to investigate the chemical constituents, pharmacological effects, and clinical applications of Yihuang Decoction. Furthermore, the study predicted the Q-marker of Yihuang Decoction by considering its effectiveness, specificity, measurability, transmissibility and traceability, and compatibility, as per the concept of Chinese medicine Q-marker. Results Yihuang Decoction exhibits pharmacological effects such as anti-inflammation and immune modulation, anti-bacteria and anti-virus properties. Clinically, it is mostly used to treat inflammation of the female reproductive system, including vaginitis, cervicitis and pelvic inflammation. According to analysis and prediction, it was suggested that allantoin, diosgenin, gallic acid, α-tocopherol, bilobalide, ginkgolide A, ginkgolide B, berberine, phellodendrine, magnoflorine, geniposidic acid and verbascoside could serve as Q-markers of Yihuang Decoction. Conclusion This review establishes a foundation for the research and development of Yihuang Decoction, and providing a crucial scientific reference for ensuring its comprehensive quality control and enhancing evaluation standards.

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Published

2024-02-20

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Data Availability Statement

The analyzed data sets generated during the study are available from the corresponding author on reasonable request.

Issue

Section

Original Research

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