Analysis on the adjuvant treatment of Jianpi Xiaoyu Recipe on the improvement of clinical symptoms and lung function in patients with stable Chronic Obstructive Pulmonary Disease

Abstract

Background To determine the efficacy of Jianpi Xiaoyu Recipe in patients with chronic obstructive pulmonary disease (COPD), we performed the analysis on its effects on clinical symptoms and lung function.Methods: 80 patients with COPD from January 2017 to January 2019 were divided into research (n=40) and control (n=40) groups by the random number table method. Patients in the control group were given routine treatment (bronchodilation, expectorant, anti-asthmatic therapies), and those of the research group received Jianpi Xiaoyu Recipe on the basis of control group. The scores for COPD assessment test (CAT), life quality, 6-minute walking test, clinical symptoms (cough, sputum, dyspnea, and suffocation), and lung function [forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), one second rate (FEV1 / FVC)] were measured, in addition to serum lipid peroxide (LPO), superoxide dismutase (SOD) activity. Results: After treatment, the scores for CAT, life quality and various clinical symptom of patients in the research group were significantly lower than those in the control group, and the distance of 6-minute walking test was significantly longer than that in the control group. After treatment, the levels of FVC, FEV1, FEV1 / FVC and serum SOD activity in patients of the research group were higher yet serum LPO level was lower than that of the control group.Conclusion: Jianpi Xiaoyu Recipe has a significant clinical effect on patients with stable COPD, which reduces clinical symptoms, improves the exercise endurance and life quality of patients, and alleviates lung dysfunction and oxidative stress response.