Clinical Efficacy of Xiaochaihu Decoction Combined with Guizhi Fuling Pill in Adjuvant Treatment of AECOPD and Its Influence on Inflammatory Factors in Patients

Abstract

Background: We analyzed the clinical efficacy of Xiaochaihu Decoction combined with Guizhi Fuling Pill in adjuvant treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods: 108 patients with AECOPD were randomly divided into control group and observation group. Patients in control group were treated with conventional therapy, while patients in observation group were treated with Xiaochaihu Decoction and Guizhi Fuling Pill on the basis of the control group. Clinical symptoms, pulmonary function, scores of modified British Medical Research Council Respiratory Questionnaire (mMRC), self-assessment test questionnaire (CAT), and the levels of inflammatory factors were compared between the two groups. Results: After treatment, total clinical effective rate of observation group was higher than that of control group (P<0.05). Compared with those before treatment, peak expiratory flow (PEF), forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity (FVC) ratio and FEV1 to predicted value ratio (FEV1% pred) in the two groups after treatment were increased (P<0.05), and those indicators in observation group were higher than those in control group (P<0.05). Compared with those before treatment, mMRC score, CAT score, procalcitonin (PCT), C-reactive protein (CRP), interleukine (IL)-18, and tumor necrosis factor (TNF)-α levels in the two groups after treatment were decreased (P<0.05), and those indicators in observation group were lower than those in control group (P<0.05).Conclusion: Xiaochaihu Decoction combined with Guizhi Fuling Pill effectively improved the clinical symptoms and lung function of patients, and smoothly regulate the levels of inflammatory factors in patients with AECOPD.