The Treatment Efficacy of Buyang Huashi Quzhuo Prescription Combined with CBP on Renal Function, Microcirculation and Inflammatory Response in Patients with Acute Renal Injury

Abstract

Objective To explore the treatment efficacy of Buyang Huashi Quzhuo prescription combined with continue blood purification (CBP) in patients with acute renal injury of qi deficiency of spleen and kidney and the accumulation of turbidity-stasis syndrome, and the effect on renal function, microcirculation and inflammatory response of patients. Methods A total of 100 patients with acute renal injury of qi deficiency of spleen and kidney and the accumulation of turbidity-stasis syndrome in our hospital from Jan. 2018 to Jan. 2021 were selected and divided into control group and observation group by using the random number table method. The control group was treated with CBP, and the observation group was treated with Buyang Huashi Quzhuo prescription on the basis of the control group. The clinical efficacy, acute physiology and chronic health evaluation score (APACHE Ⅱ), renal function, microcirculation and the levels of inflammatory factors of the both groups were compared before and after treatment. Results The total effective rate in the observation group was obviously higher than that in the control group. The APACHE Ⅱ score, and the levels of serum creatinine, urea nitrogen as well as urinary albumin excretion rate, 24 h urinary protein quantification, β₂-microglobulin, interleukin-6, interleukin-8 and C-reactive protein of both groups after treatment were obviously decreased in comparison with those before treatment, and those in observation group were obviously lower than those in the control group. Conclusion The clinical efficacy of Buyang Huashi Quzhuo prescription combined with CBP in the treatment of patients with acute renal injury of qi deficiency of spleen and kidney and the accumulation of turbidity-stasis syndrome is significant, and it can improve the renal function as well as microcirculation of patients and reduce the inflammatory response of body.