Clinical study of Angong Niuhuang pills combined with cinepazide maleate for treating patients with severe acute craniocerebral injury

Abstract

Objective To investigate the clinical effects of Angong Niuhuang pills combined with cinnarizide maleate in treating patients with severe acute craniocerebral injury. Methods A total of 120 patients with severe acute craniocerebral injury who received treatment in our hospital from December 2018 to October 2021 were randomly divided into a control group and an observation group, with 60 cases in each group. Both groups were given routine treatment, the control group was additionally given cinepazide maleate, and the observation group was treated with Angong Niuhuang pill on the basis of the control group. The levels of neurotransmitters, vascular endothelial function and cerebral blood flow as well as adverse reactions were compared between the two groups. Results After treatment, the neuron specific enolase (NSE) and endothelin (ET) levels, wave velocity (Wv) of cerebrovascular pulse wave and R value in the two groups were significantly lower than those before treatment (P<0.05), and the levels in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and angiotensin I (Ang-I) levels, the mean volume of cerebral blood flow (Qmean) and the mean velocity of cerebral blood flow (Vmean) in the two groups were obviously higher than those before treatment (P<0.05), and the levels in the observation group were evidently higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Angong Niuhuang pill combined with cinepazide maleate has a significant effect on patients with severe acute craniocerebral injury, which helps to regulate the level of neurotransmitters, and improve their vascular endothelial function and cerebral blood flow indicators, and its effect is safe and reliable.