Pharmacological Activities of a Chinese Herb, Glycine tomentella (I-Tiao-Gung): A Systematic Review

Bonnie Sun Pan; Tsui-Yao Chen; Whae-Ling Chuang

doi:10.62767/jecacm601.3729

Authors

Bonnie Sun Pan Food Science Department, Taiwan Ocean University, No.2, Beining Road, 20224 Keelung, Taiwan, China Author
Tsui-Yao Chen Department of Food Science, Ilan University, No.1, Sec. 1, Shennong Road, 26007 Yilan, Taiwan, China Author
Whae-Ling Chuang Great Wall Enterprise Co. Ltd., No. 501., Sec. 6, Changrong Road, Liuying District, 73663 Tainan, Taiwan, China Author

DOI:

https://doi.org/10.62767/jecacm601.3729

Keywords:

I-Tiao-Gung, Glycine tomentella, isoflavone, anti-inflammatory, anti-oxidative, anti-stress, blood thinning, hypolipidemia

Abstract

I-Tiao-Gung, Glycine temetella Hayata, has been used as a traditional herbal medicine for pain relief. This review provides science-based evidences that support the traditional concept. The 95 % ethanol extract of I-Tiao-Gung root (GTE) is an isoflavone-rich flavonoid mixture. It has the bioactivities including anti-inflammation by inhibiting plasma COX-2 and TNF-α gene expression in a macrophage-like cell line from Atlantic salmon (TO cells) and in vivo tests on tilapia and guppy. GTE was anti-oxidative to plasma LDL in both in vitro and ex vivo studies. It also showed activities of blood thinning, preventive to erythrocytes aggregation, upregulating EPA synthesis in erythrocyte membrane, enhancing adaptation to cold and heat stresses in tilapia, grouper and ornamental fishes. These fishes served as alternative animal models to verify the efficacy of GTE used in herbal medicine. It also has more pharmacological effects to be considered.

References

Hymowitz T, Hsieh JS. The use of Glycine tomentella Hyata on the islet of Kinmen (Quemoy). Economic Botany 2002; 56(3): 287-289.

Huang SS, Huang CH, Ko CY, et al. An ethnobotanical study of medicinal plants in Kinmen. Frontiers in Pharmacology 2022; 12: 681190.

Ko YJ, Hsieh WC, Chiao NY, et al. Pharmacobotanical studies of crude drug I-Tiao-Gung commercially available on the market. Journal of Chinese Medical Sciences 1999; 8(3): 33–46.

Lu TC, Ko YZ, Huang HW, et al. Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. Journal of Ethnopharmacology 2007; 113: 142-148.

Pan BS, Kuo YY, Chen TY, et al. Anti-oxidative and anti-inflammatory activities of two different species of a Chinese herb I-Tiao-Gung. Life Sciences 2005; 77: 2830-2839.

Wu SM, Tseng YJ, Lin JJ, et al. Mitigation of stress and water deterioration with a root extract of Glycine tomentella during simulated transport of orange-spotted grouper (Epinephelus coioides). Aquaculture 2020; 514: 734485.

Chuang WL, Haugland Ø, Pan BS, et al. Isoflavone-rich extracts from wooly glycine Glycine tomentella inhibits LPS-induced TNF-α expression in a macrophage cell line of Atlantic salmon (Salmo salar L.). Molecular Immunology 2008; 45: 3956-3964.

Chuang WL, Pan BS. Anti-stress effect of Glycine tomentella Hayata in tilapia: inhibiting COX-2 expression and enhancing EPA synthesis in erythrocyte membrane and fish growth. Journal of Agricultural and Food Chemistry 2011; 59(17): 9532-9541.

Chen TY, Shiao MS, Pan BS. Inhibition of 12- and 15-lipoxygenase activities and protection of human and tilapia low-density lipoprotein oxidation by I-Tiao-Gung (Glycine tomentella). Lipids 2005; 40(11): 1171-1177.

Chen TY, Pan BS. Ex vivo inhibitory effect on tilapia LDL oxidation and hypolipidemia properties of Glycine tomentella root extract. Comparative Biochemistry and Physiology Part A 2007; 148(1): 189-195.

Wu SM, Chen JR, Chang CY, et al. Potential benefit of I-Tiao-Gung (Glycine tomentella) extract to enhance ornamental fish welfare during live transport. Aquaculture 2021; 534: 736304.

Huang SC, Lin JJ, Lee MF, et al. Freshwater clam extracts alleviate dyslipidemia of tilapia fed a high-fat diet as an animal model. Journal of Functional Foods 2016; 25: 559-567.

Lin JJ, Liu YC, Chang CJ, et al. Hepatoprotective mechanism of freshwater clam extract alleviates non-alcoholic fatty liver disease elucidated in vitro and in vivo models. Food & Function 2018; 9(12): 6316-6326.

Lin JT, Liu SC, Tsay GJ, et al. Composition of flavonoids and phenolic acids in Glycine tomentella Hayata cultivated in various soils. Food Chemistry 2010; 121(3): 659-665.

Lin SJ, Lay HL, Wu ST, et al. Contents of certain isoflavones in Glycine dolichocarpa, G. tobacina and G. tomntella collected in Taiwan. Journal of Food and Drug Analysis (JFDA) 2005; 13(3): Article 4.

Tan Y, Zhang X, Cheang WS. Isoflavones daidzin and daidzein inhibit lipopolysaccharide-induced inflammation in RAW264.7 macrophages. Chinese Medicine 2022; 17(1):95.

Wu KC, Chiang BJ, Tsai WH, et al. I-Tiao-Gung extract through its active component daizin improves cyclophosphamide-induced bladder dysfunction in rat model. Neurourology and Urodynamics 2018; 37(8): 2560-2570.

Yen JH, Yang DJ, Chen MC, et al. Glycine tomentella Hayata inhibits MMP-9 activity, and enhances RAW264.7 macrophage clearance of apoptotic cells. Journal of Biomedical Science 2010; 17: 83.

Ko YJ, Wu YW, Lin WC. Hypolipidemic effect of Glycine tomentella root extract in hamsters. The American Journal of Chinese Medicine 2004; 32: 57-63.