Efficacy of modified Duhuo Jisheng decoction combined with diosmine in the treatment of lumbar spinal stenosis and its effect on serum factors

Abstract

Objective To analyze the efficacy of modified Duhuo Jisheng decoction combined with diosmine in the treatment of lumbar spinal stenosis (LSS) and its effect on serum factors. Methods 118 patients with LSS who were treated in our hospital from February 2019 to February 2022 were randomly divided into a control group and an observation group, with 59 cases in each group. Patients in both groups were given conventional treatment, and patients in the control group was given diosmine on this basis, while patients in the observation group was given a modified Duhuo Jisheng decoction treatment on the basis of the control group. The traditional Chinese medicine (TCM) symptom scores, serum factor level and scores of visual analog scale (VAS), Oswestry Disability Index questionnaire (ODI), and activity of daily living (ADL) scores were compared between the two groups. Results After treatment, in both groups, 6 items of TCM symptom scores, neuropeptide Y (NPY), 5-hydroxytryptamine (5-HT), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) levels and scores of VAS and ODI were significantly lower than those before treatment (P<0.05), and these levels in the observation group were significantly lower than those in the control group (P<0.05); after treatment, the ADL score of the two groups was significantly higher than that before treatment (P<0.05), and the ADL score of the observation group was significantly higher than that of the control group (P<0.05). Conclusion The combination of modified Duhuo Jisheng decoction and diosmin can effectively alleviate the clinical symptoms of patients with LSS, help to regulate serum factor levels, reduce the pain of patients, and improve the ability of daily living and the activities of patients.