Effects of integrated traditional Chinese and Western medicine on inflammatory factors and endothelial function in ACS patients after PCI

Abstract

Objective To explore the effects of integrated traditional Chinese and Western medicine on inflammatory factors and vascular endothelial function in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Method A total of 86 ACS patients treated by PCI in our hospital from Jan. 2017 to Jul. 2018 were selected, and they were divided into the control group (n=43) and observation group (n=43) by random number table method. The patients in the two groups were given conventional treatment, and the control group added atorvastatin treatment on the basis of the conventional treatment, and the observation group added Danshen Chuanxiongqin injection treatment on the basis of the conventional treatment. The levels of high sensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), von willebrand factor (vWF), endothelin-1 (ET-1) and incidence of adverse cardiac events in the two groups were compared before and after treatment. Results After treatment, the levels of hs-CRP, TNF-α and IL-6 in both groups was significantly lower than those before treatment (P<0.05), and the levels of hs-CRP, TNF-α and IL-6 in observation group were significantly lower than those in the control group (P<0.05); the levels of ET-1 and vWF in both groups were significantly lower than those before treatment, and the levels of ET-1 and vWF in the observation group were significantly lower than those in the control group (P<0.05); there was no significant difference in the incidence of adverse cardiac events between the two groups (P>0.05). Conclusion The integrated traditional Chinese and Western medicine can down-regulate the levels of inflammatory factors in patients with ACS after PCI, improve vascular endothelial function and decrease the occurrence of adverse cardiac events.