Effects of Wenshen Nuangong formula on pain and PGE2, PGF2α and VEGF levels in patients with cold congelation and blood stasis type of endometriosis dysmenorrhea

Abstract

Objective To explore the effects of Wenshen Nuangong formula on pain and levels of prostaglandin E₂ (PGE₂), prostaglandin F_2α (PGF_2α) and vascular endothelial growth factor (VEGF) in patients with cold coagulation and blood stasis type of endometriosis (EM) dysmenorrhea. Methods From June 2019 to June 2021, 100 patients with cold coagulation and blood stasis type of EM dysmenorrhea admitted to our hospital were selected as research objects, and were divided into a control group and an observation group using the random number table method, with 50 cases in each group. The control group was treated with oral mifepristone tablets, and the observation group was treated with Wenshen Nuangong formula on the basis of the treatment used in the control group. The pain, PGE₂ level, PGF_2α level, VEGF level, traditional Chinese medicine (TCM) syndrome scores and adverse reactions before and after treatment were compared between the two groups. Results After treatment, COX dysmenorrhea symptom scale scores, visual analogue scale (VAS) scores, PGE₂ level, PGF_2α level, VEGF level, and TCM symptom scores were significantly lower than those before treatment (P<0.05), and the levels in the observation group were significantly lower than those in the control group (P<0.05). After treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Wenshen Nuangong formula can effectively alleviate pain, relieve clinical symptoms, and reduce serum PGE₂, PGF2_2α, and VEGF levels of patients with cold coagulation and blood stasis type EM dysmenorrhea, with significant efficacy and safety.