Efficacy of Bufei Sanjie Decoction in Adjuvant Treatment of Advanced Lung Cancer with the Pattern of Qi Deficiency and Phlegm Obstruction and its Effect on Serum Index

Abstract

Objective: The work explored the clinical efficacy of treatment of Bushen Sanjie decoction combined with apatinib mesylate in patients with advanced lung cancer of the pattern of qi deficiency and phlegm obstruction and its effect on serum index. Methods: A total of 128 patients with advanced lung cancer of the pattern of qi deficiency and phlegm obstruction in our hospital from Jun. 2018 to Jun. 2020 were divided into control group (n=64) and study group (n=64) by using the random number table method. Control group was treated with apatinib mesylate and study group was treated with Bufei Sanjie decoction combined with apatinib mesylate. The clinical efficacy, serum index, tumor marker, quality of life before and after treatment, and adverse reaction were compared between the two groups. Results: The total effective rate was obviously higher in the study group than in the control group (P<0.05). The levels of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), cytokeratin fragment 19 (CYFRA21-1), carcino-embryonic antigen (CEA) and neuron-specific enolase (NSE) of both groups after treatment were obviously decreased in comparison with those before treatment (P<0.05), and those in study group were obviously decreased in comparison with those in control group (P<0.05). The life quality score of both groups after treatment obviously increased in comparison with that before treatment (P<0.05), and that in study group obviously increased in comparison with that in control group (P<0.05). The adverse reaction rate was obviously lower in study group than that in control group (P<0.05). Conclusion: The clinical efficacy of Bufei Sanjie decoction combined with apatinib mesylate in the treatment of advanced lung cancer patients with the pattern of qi deficiency and phlegm obstruction was significant and it could inhibit the tumor angiogenesis, decrease tumor marker level and improve the life quality of patients.