Observation on the Clinical Efficacy of Combination therapy of Jiangu Buyuan Zhuyu Decoction and Western Medicine in the Treatment of POP

Abstract

Background To explore the efficacy of combination therapy of Jiangu Buyuan Zhuyu decoction and Alendronate Sodium tablets and Caltrate D tablets in patients with primary osteoporosis (POP).Methods: 130 patients with POP were divided into control group and observation group, with 65 cases in each group. The patients in the control group were treated with Alendronate Sodium tablets and Caltrate D tablets. In addition to the therapy applied to the control group, those patients in the observation group were treated with Jiangu Buyuan Zhuyu decoction. The numerical rating scale (NRS), Oswestry disability index (ODI), bone mineral density (BMD), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRACP), β-crosslaps (β-CTX), serum calcitonin (CT) levels and the occurrence of adverse effects were compared before and after treatment. Results: After treatment, the total effective rate in the observation group was obviously higher than that in the control group, and the observation indexes of both groups were lower, and those in the observation group were lower than the control group. The BMD in femoral neck, Wards triangle, lumbar vertebrae L₂-L₄ and CT of both groups were higher after treatment, and those in the observation group was higher than that in the control group. There was no significant difference concerning the incidence of adverse effects.Conclusion: Combination therapy of Jiangu Buyuan Zhuyu decoction, Alendronate Sodium tablets, and Caltrate D tablets has significant efficacy in the treatment of POP, with pain reduction, BMD improvement, and bone metabolism regulation.