Value of Lymphocyte Subsets Combined with Immunoglobulin for the Diagnosis of Henoch-Schönlein Purpura Complicated by Gastrointestinal Symptoms in Children

Abstract

Objective: To explore the diagnostic value of lymphocyte subsets combined with immunoglobulin in children with Henoch-Schonlein purpura complicated with gastrointestinal symptoms. Methods: The clinical data of 80 children with Henoch-Schonlein purpura treated in our hospital from December 2017 to December 2022 were retrospectively analyzed. According to the symptoms of Henoch-Schonlein purpura, the children were divided into a complicated group and a simple group. 40 children with Henoch-Schonlein purpura complicated with gastrointestinal symptoms were assigned as the complicated group. 40 cases of purpura simplex with skin purpura as the first symptom were set as the simple group. The general data, lymphocyte subsets, and immunoglobulin were compared between the two groups, and the correlation between natural killer (NK) cell count or immunoglobulin (Ig) A, IgE and IgG levels and gastrointestinal symptoms of children with Henoch-Schonlein purpura were compared by Spearman method. Results: The complicated group had lower NK cell count, and IgA and IgG levels, and higher IgE level compared to the simple group (p < 0.05). The NK cell count, and IgA and IgG levels were negatively, while IgE level was positively correlated with Henoch-Schonlein purpura complicated with gastrointestinal symptoms (p < 0.05). The AUC values of NK cell count and levels of IgA, IgE and IgG in the diagnosis of Henoch-Schonlein purpura complicated with gastrointestinal symptoms in children were 0.649, 0.644, 0.829 and 0.969, respectively (p < 0.05). Conclusion: Lymphocyte subsets combined with immunoglobulin may have a good diagnostic value for children with Henoch-Schonlein purpura complicated with gastrointestinal symptoms. The decrease of NK cell count and IgA and IgG levels, and the increase of IgE level may indicate children with henoch-Schonlein purpura complicated with gastrointestinal symptoms.