A Clinical Research on The Intervention of Xuanfei Tongfu Decoction on Gastrointestinal Dysfunction in Patients With Acute Lung Injury

Abstract

Objective: To explore the curative effect of Xuanfei Tongfu Decoction on gastrointestinal dysfunction in patients with acute lung injury based on the theory of ”lung and large intestine are in harmony with each other”. Methods: Fifty patients with acute lung injury treated with Xuanfei Tongfu Decoction combined with lactulose oral liquid in our hospital were collected as the combination group, and 50 patients of the same type treated with only lactulose oral liquid in the same department during the same period were collected as the control group. The clinical symptom scores of the two groups were compared, and the changes of gastrointestinal hormones and inflammation indexes were sorted out according to the case information，and their safety was analyzed. Results: After 7 days of treatment，the clinical symptom scores of both groups decreased，and the combined group was lower than the control group (p < 0.05). Serum motilin，gastrin and vasoactive intestinal peptide levels were increased in both groups (p < 0.05), while tumor necrosis factor, interleukin-6 and IL-1β levels were decreased in both groups (p < 0.05), and the changes in combination group were greater than those in control group (p < 0.05). There was no statistical significance in the occurrence of adverse reactions between the two groups (p < 0.05). Conclusion: Based on the theory of “lung and large intestine are in harmony with each other”, Xuanfei Tongfu Decoction may have a better effect on gastrointestinal dysfunction in patients with acute lung injury, which can improve gastrointestinal function and reduce inflammatory response，and has good safety.