Research Progress on Intelligent Drug Delivery Systems in Chronic Inflammatory Diseases
DOI:
https://doi.org/10.62767/jecacm701.7821Keywords:
chronic inflammatory diseases, intelligent drug delivery system, personalized treatment, response, carrierAbstract
Chronic inflammatory diseases are a serious challenge in global public health, and traditional routes of administration have many limitations due to their lack of precision and controllability. As an innovative drug delivery strategy, intelligent drug delivery system (IDDS) has attracted widespread attention. This dosage form can respond to internal and external stimuli (such as changes in pH, temperature, enzyme activity, light sensitivity, and magnetic sensitivity), thereby achieving precise and selective release of drugs. This article systematically reviews electronic databases (PubMed, Web of Science, ScienceDirect, and CNKI) to find studies published between 2012 and 2025, focusing on the core characteristics of the chronic inflammatory microenvironment and its guiding significance in the design of IDDS. This article highlights the construction strategies and response mechanisms of various IDSS, including nanoparticles, liposomes, hydrogels, cell membrane-based biomimetic systems, and prodrug strategies, as well as their application progress in chronic inflammatory diseases such as inflammatory bowel disease, arthritis, skin diseases, respiratory diseases, liver and kidney diseases, ocular diseases, and cardiovascular diseases. The article also explores the mechanisms and advantages of IDDS in targeted delivery, controlled release, and various responsive systems (such as pH, enzyme, magnetic, thermal, light, and ultrasound), and investigates the benefits, challenges, and future application prospects of the latest research and application advances in the treatment of chronic inflammatory diseases. These IDDS has opened up new paths for enhancing therapeutic efficacy, reducing toxic side effects, and enabling personalized treatment in chronic inflammatory diseases, offering new hope for future medical treatment.
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