Therapeutic Effect of lipoic Acid Injection Intointo Patients with Cerebral Infarction and its Effects on Inflammatory Factors and Oxidative Stress

Abstract

Objective To analyze the therapeutic effect of lipoic acid injection on patients with cerebral infarction and its effects on inflammatory factors and oxidative stress. Methods A total of 110 patients with cerebral infarction who were treated in our hospital from June 2018 to June 2020 were selected as the research subjects. All the 110 patients were randomly divided into observation group (n=55) and control group (n=55) according to the random number table method. The patients in the control group were treated with routine therapy, while those in the observation group were treated with lipoic acid injection on the basis of the control group. The clinical efficacy, levels of inflammatory factors [interleukin-6 (IL-6), interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM-1)] and oxidative stress indexes [total antioxidant capacity (T-AOC), malondialdehyde (MDA)] were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). After treatment, the levels of IL-6, IL-8 and sICAM-1 in the two groups were significantly lower than those before treatment (P<0.05), and the levels of IL-6, IL-8 and sICAM-1 were greatly lower in the observation group than those in the control group (P<0.05). Also, after treatment, the level of T-AOC (P<0.05) and MAD (P<0.05) in the two groups were significantly higher and lower than those before treatment (P<0.05), respectively. Noticeably, the levels of T-AOC (P<0.05) and MDA (P<0.05) were greatly higher and lower in the observation group than those in the control group, respectively. Conclusion Lipoic acid injection was effective in treating patients with cerebral infarction, as it could not only reduce the release of inflammatory factors, but also improve the oxidative stress response of the body and promote the recovery of brain tissues.