Application of Low-frequency Repetitive Transcranial Magnetic Stimulation in Patients with Sleep Disorders after Traumatic Brain Injury

Jiaming Xu; Luting Zhou

doi:10.62767/dbm501.1875

Authors

Jiaming Xu Department of Emergency, Ningbo Medical Center Li Huili Hospital, 315100 Ningbo, Zhejiang, China Author
Luting Zhou Department of Electrophysiology, Ningbo Medical Center Li Huili Hospital, 315100 Ningbo, Zhejiang, China Author

DOI:

https://doi.org/10.62767/dbm501.1875

Keywords:

low-frequency repetitive transcranial magnetic stimulation, traumatic brain injury, sleep disorder, adverse reaction

Abstract

Objective: Our study aims to explore the application of low-frequency repetitive transcranial magnetic stimulation (rTMS) in patients with sleep disorders after traumatic brain injury (TBI). Methods: 47 patients with sleep disorders after TBI, who received rTMS combined with conventional treatment in our hospital from January 2022 to May 2023, were allocated into the observation group, and 43 patients with sleep disorders after TBI receiving conventional treatment during the same period were assigned into the control group. The clinical efficacy and adverse reaction in the two groups were compared, and the differences of sleep disorder score and neurotrophic factor expression before and after treatment were observed. Results: The total effective rate of clinical efficacy was significantly higher and the total incidence of adverse reaction was obviously lower in observation group than those in control group (p < 0.05). After treatment, pittsburgh sleep quality index was visibly decreased in both groups (p < 0.05), and that in the observation group was significantly lower than that in the control group (p < 0.05). The levels of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor were markedly increased in both groups (p < 0.05), and those in the observation group was significantly higher than those in the control group (p < 0.05). Conclusion: RTMS has a good clinical efficacy in the treatment of sleep disorders after TBI, which has a good effect in improving sleep disorders and expressions of neurotrophic factors, with high safety.

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