Study on the Correlation Between Serum Macrophage Migration Inhibitory Factor and Cognitive Impairment after Stroke and Its Relationship with Serum Inflammatory Factors

Abstract

Objective: To analyze the correlation between serum macrophage migration inhibitory factor (MIF) and cognitive impairment after stroke, as well as its relationship with serum inflammatory factors. Methods: Stroke patients in our hospital from September 2022 to June 2023 were included as the research subjects. They were divided into the control group (without cognitive impairment, n = 43) and the observation group (with cognitive impairment, n = 51) based on whether cognitive impairment occurred. The levels of serum factors and cognitive functions of the two groups were compared, the multiple factors influencing cognitive impairment after stroke were analyzed, and the correlation between the level of serum macrophage MIF and cognitive impairment or inflammatory factors was explored. Results: The levels of serum tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6), and MIF were lower, while the scores of the Montreal Cognitive Scale (MoCa) and the Mini-Mental State Examination (MMSE) were higher in the control group than in the observation group (p < 0.05). Combined diabetes, hypertension, hyperlipidemia, TNF-α, IL-6, and MIF were risk factors affecting cognitive impairment after stroke (p < 0.05). MIF was negatively correlated with both MoCA and MMSE scores (p < 0.05), and positively correlated with the levels of TNF-α and IL-6 (p < 0.05). Conclusion: The levels of serum TNF-α, IL-6 and MIF have a certain correlation with cognitive impairment in stroke patients, the abnormal increase of which is a risk factor affecting the occurrence of cognitive impairment in stroke patients. Early detection of serum levels of TNF-α, IL-6 and MIF in patients can effectively prevent the occurrence of cognitive impairment and improve the prognosis of patients.