Correlation of Serum UCH-L1 and Del-1 Levels with Cerebral Infarction Size and Prognosis and Their Diagnostic Value in Patients with Acute Cerebral Infarction

Yuedong Li; Jinlan Lu

doi:10.62767/

Authors

Yuedong Li Department of Neurology, Dongyang Red Cross Hospital, 322100 Dongyang, Zhejiang, China Author
Jinlan Lu Department of Neurology, Dongyang Red Cross Hospital, 322100 Dongyang, Zhejiang, China Author

DOI:

https://doi.org/10.62767/

Keywords:

acute cerebral infarction, cerebral infarction size, ubiquitin C-terminal hydrolase L1, developmental endothelial locus-1, prognosis

Abstract

Objective: To explore the correlation of serum ubiquitin C-terminal hydrolase L1 (UCH-L1) and developmental endothelial locus-1 (Del-1) levels with cerebral infarction size and prognosis and their diagnostic value in patients with acute cerebral infarction. Methods: 60 patients with acute cerebral infarction who received medical treatment in our hospital from January 2022 to March 2024 were selected as the diseased group, and the other 60 healthy people who underwent physical examination during the same period were selected as the healthy group. The diseased group was divided into small and medium area group (n = 46) and large area group (n = 14) according to the size of the cerebral infarction, and into good prognosis group (n = 38) and poor prognosis group (n = 22) in line with the modified Rankin Scale (mRS) score. Serum UCH-L1 and Del-1 levels, cerebral infarction size and mRS scores were compared among all groups. Spearman rank correlation analysis was used for correlation analysis, and area under receiver Operating characteristic (ROC) curve (AUC) was applied to analyze the diagnostic value of each parameter. Results: The serum UCH-L1 level was higher and the Del-1 level was lower in the diseased group than in the healthy group (p < 0.05). The cerebral infarction size and serum UCH-L1 level were lower while the Del-1 level was higher in the small and medium area group than those in the large area group (p < 0.05). mRS scores and serum UCH-L1 level were lower and Del-1 level was higher in the good prognosis group compared to poor prognosis group (p < 0.05). Serum UCH-L1 level was positively correlated while Del-1 level was negatively correlated with cerebral infarction size and mRS Score (p < 0.05). The AUC values of serum UCH-L1 and Del-1 alone and combined in predicting large area cerebral infarction were 0.782, 0.781 and 0.797, respectively, and the AUC values of serum UCH-L1 and Del-1 alone and combined in predicting poor prognosis were 0.739, 0.765 and 0.794, respectively, which were all greater than 0.7 (p < 0.05). Conclusion: Serum UCH-L1 level is positively, while Del-1 level is negatively correlated with cerebral infarction size and mRS Score in patients with acute cerebral infarction. The combined serum UCH-L1 and Del-1 has high diagnostic value and can be used as an indicator for clinical evaluation of acute cerebral infarction.

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