Effects of Hyperbaric Oxygen Combined with MGS on Electroencephalogram and Oxidative Stress Indicators in Patients with Traumatic Epilepsy

Abstract

Objective To analyze the effect of hyperbaric oxygen combined with monosialotetrahexosyl ganglioside sodium (MGS) on electroencephalogram (EEG) and oxidative stress indicators in patients with traumatic epilepsy. Methods 124 patients with traumatic epilepsy in our hospital from January 2018 to August 2020 were selected and divided into the control group and observation group by random number table method, 62 cases in each group. The control group was treated with conventional anti-epileptic drugs combined with MGS, and the observation group was treated with hyperbaric oxygen on the basis of the control group. The improvement of clinical symptoms, EEG outcome and oxidative stress level in the two groups were compared. Results After treatment, the epileptic seizure frequency and duration in the two groups were evidently lower than those before treatment (P<0.05), and the epileptic seizure frequency and duration in the observation group were apparently lower than those in the control group (P<0.05); after treatment, the total effective rate in the observation group was obviously higher than that in the control group (P<0.05); after treatment, the levels of nitric oxide (NO) and total antioxidant capacity (T-AOC) in the two groups were significantly higher than those before treatment (P<0.05), and the level of malondialdehyde (MDA) was apparently lower than that before treatment (P<0.05), and the levels of NO and T-AOC in the observation group were obviously higher than those in the control group (P<0.05), the level of MDA in the observation group was apparently lower than that in the control group (P<0.05). Conclusion Combined application of hyperbaric oxygen and MGS in the treatment of traumatic epilepsy can effectively reduce the clinical symptoms of patients, reduce the level of oxidative stress, with a good curative effect.