Clinical Efficacy of Quetiapine-assisted Brintellix in the Treatment of TRD Patients and the Effect on Nerve Factor and Cognitive Function

Abstract

Objective This work explored the clinical efficacy of treatment of quetiapine fumarate tablets combined with vortioxetine hydrobromide tablets (brintellix) in patients with treatment resistant depression (TRD), and the effect of cognitive function and nerve factor. Methods A total of 116 TRD patients in our hospital from Aug. 2018 to Aug. 2020 were selected and divided into control group (n=58) and study group (n=58) by the random number table method. Control group and study group were treated with brintellix and quetiapine fumarate tablets combined with brintellix, respectively. The clinical efficacy, nerve factor, montreal cognitive assessment scale (MOCA) score, hamilton depression scale (HAMD) score and occurrence of adverse reactions of two groups were compared before and after treatment. Results The total effective rate was obviously lower in control group than that in study group (P<0.05). The levels of myelin basic protein (MBP), neuron-specific enolase (NSE) and HAMD score of both groups were obviously decreased after treatment relative to before treatment (P<0.05), and those in control group after treatment were obviously increased in comparison with those in study group after treatment (P<0.05). The level of brain derived neurotrophic factor (BDNF) and MOCA score were obviously increased after treatment in contrast with before treatment (P<0.05), and those of control group after treatment were obviously declined in comparison with those of study group after treatment (P<0.05). There was no significant difference in the incidence rate of adverse reactions between control group and study group (χ²=0.048, P=0.826). Conclusion Quetiapine fumarate tablets combined with brintellix had significant efficacy in the treatment of TRD patients, and it could improve nerve factor level and nerve function, alleviate the degree of depression and raise cognitive function of patients.