Study on the Relationship and Application of TNF-α, CRP, NGF and Cerebral Edema in Patients with Acute Cerebral Hemorrhage

Abstract

Objective To analyze the relationship between tumor necrosis factor-α, C-reactive protein, nerve growth factor and brain edema in patients with acute cerebral hemorrhage and its clinical application. Methods A total of 120 patients with acute cerebral hemorrhage who attended our hospital between April 2019 and May 2020 were enrolled. According to the severity of cerebral edema, the subjects were divided into mild, moderate, and severe group. The serum levels of TNF-α, CRP and NGF were measured and compared in the three groups. According to the prognosis, the subjects were divided into two groups, namely, the survival group and the death group. Spearman correlation was used to analyze the correlation between TNF-α, CRP and NGF levels and the severity of brain edema in patients. The diagnostic value of these three indicators was compared by the receiver operating curve and the area under curve. Results The levels of TNF-α, CRP and NGF in the moderate and severe groups were significantly higher than those in the mild group, and the levels of TNF-α, CRP and NGF in the severe group were noticeably higher than those in the moderate group. According to Spearman correlation analysis, serum levels of TNF-α, CRP and NGF were positively correlated with brain edema in patients with acute cerebral hemorrhage. The levels of TNF-α, CRP and NGF in the survival group were greatly lower than those in the death group. The AUC values of TNF-α, CRP and NGF were 0.860, 0.843 and 0.885, respectively, which showed high predictive performance for the prognosis of patients with acute cerebral hemorrhage. Conclusion The levels of TNF-α, CRP and NGF are closely related to the severity of cerebral edema in patients with acute cerebral hemorrhage, and these indicators are highly effective in evaluating the condition of cerebral edema in patients.