The Effects of Donepezil Combined with Butylphthalide on Endothelial Function, Oxidative Stress and Cognitive Function of Patients with Vascular Dementia

Abstract

Objective To investigate the effect of donepezil combined with butylphthalide on endothelial function, oxidative stress and cognitive function in patients with vascular dementia (VD). Methods A total of 102 patients with VD admitted to our hospital from September 2017 to October 2019 were randomly divided into observation group (51 cases), which was treated with butylphthalide and control group (51 cases), which was treated with donepezil on the basis of the control group. The endothelial function, oxidative stress and cognitive function of the two groups of patients were observed before and after treatment. Results After treatment, the MMSE scores of the two groups were higher than those before treatment (P<0.05), and the observation group was greatly higher than the control group (P<0.05). After treatment, the levels of endothelin (ET) and nitric oxide (NO) in the two groups were significantly lower than those before treatment (P<0.05), and the observation group was obviously lower than the control group (P<0.05). After treatment, the levels of malondialdehyde (MDA) in the two groups were sharply lower than those before treatment (P<0.05), and the observation group was greatly lower than the control group (P<0.05). Moreover, compared with before treatment, the levels of superoxide dismutase (SOD) in the two groups were significantly higher than those before treatment (P<0.05), and the observation group was noticeably higher than the control group after treatment (P<0.05). Conclusion Donepezil combined with butylphthalide showed a high efficacy in the treatment of VD patients, and the combined therapy  can improve the cognitive function, endothelial function and oxidative stress of patients with VD.