Analysis of the Effect of Cerebrospinal Fluid Circulation Reconstruction on Serum Indexes and Long-term Prognosis of Patients with sTBI Based on Decompressive Craniectomy

Abstract

Objective To investigate the effect of decompressive craniectomy combined with cerebrospinal fluid circulation reconstruction on serum indexes and long-term prognosis of patients with severe traumatic brain injury (sTBI). Methods A total of 120 patients with sTBI who were treated in our hospital from January 2019 to December 2020 were selected and randomly divided into the control group and the observation group, with 60 cases in each. The control group applied the treatment of decompressive craniectomy, and the observation group applied the treatment of decompressive craniectomy combined with cerebrospinal fluid circulation reconstruction. We compared the intracranial pressure (ICP), serum indexes, complications and prognosis of the two groups before and after treatment. Results At 3 days and 7 days after operation, the ICP of the two groups was significantly lower than that before operation (P<0.05), and the observation group was significantly lower than that of the control group (P<0.05). At 7 days after operation, the levels of cortisol, neuron-specific enolase (NSE) and central nerve-specific protein (S100β protein) in the two groups were significantly lower than those before surgery (P<0.05), and the observation group were significantly lower than those in the control group (P<0.05). The total incidence of complications in the observation group was significantly lower than that in the control group (P<0.05). The prognosis of patients in the observation group was significantly better than that in the control group (P<0.05). Conclusion Cerebrospinal fluid circulation reconstruction is a safe and reliable treatment modality that could effectively reduce ICP in patients with sTBI, mitigate brain tissue damage, protect neurological function and improve the prognosis of patients.