Study on the Level Changes and Diagnostic Values of FIB, Hcy and UA in Type 2 Diabetes Mellitus Patients with Cerebral Infarction

Abstract

Objective To investigate the level changes and diagnostic values of fibrinogen (FIB), homocysteine (Hcy) and uric acid (UA) levels in type 2 diabetes mellitus (T2DM) patients with cerebral infarction. Methods A total of 60 T2DM patients with cerebral infarction treated in our hospital from Jan. 2018 to Dec. 2019 were selected as the observation group, and they were divided into the mild group (n=22), moderate group (n=19) and severe group (n=19) according to the severity of cerebral infarction, and 60 cases of healthy people who accepted physical examination for the same period were selected as control group. The levels of FIB, Hcy and UA were compared among groups, and the diagnostic values of the FIB, Hcy and UA levels alone and in combination in T2DM with cerebral infarction were evaluated using receiver operating characteristic curve (ROC), and the correlation between the levels of FIB, Hcy and UA and the severity of T2DM patients with cerebral infarction was analyzed by Spearman correlation analysis. Results The levels of FIB, Hcy and UA in the observation group were significantly higher than those in the control group; The AUC value of the combined detection of FIB, Hcy and UA levels was significantly higher than that of single detection for each index; The levels of FIB and Hcy in the moderate and severe groups were significantly higher than those in the mild group, there was no significant difference in UA level between the moderate group and mild group, the UA level in the severe group was significantly higher than that in the mild group, and the level of Hcy in the severe group was significantly higher than that in the moderate group, there were no significant difference in FIB and UA levels between the moderate group and severe group; after Spearman correlation analysis, the levels of FIB, Hcy and UA were positively correlated with the severity of T2DM with cerebral infarction (r=0.490, 0.730, 0.439, P<0.01). Conclusion The levels of FIB, Hcy and UA were elevated with the increase of the severity of T2DM patients with cerebral infarction, and the combined detection of FIB, Hcy and UA levels is of great value in the diagnosis of  T2DM with cerebral infarction.