Effects of Hyperbaric Oxygen-Assisted Naoxintong Capsule Therapy on Hemodynamics and Hemorheology in Patients with Hypertensive Cerebral Hemorrhage

Abstract

Objective To investigate the effect of hyperbaric oxygen-assisted Naoxintong capsule therapy on hemodynamics and hemorheology in patients with hypertensive intracerebral hemorrhage (HICH). Methods A total of 110 patients with HICH who were treated in our hospital from March 2019 to December 2021 were selected and divided into control group and observation group by random number table method, with 55 cases in each group. The control group was given routine treatment combined with Naoxintong capsule, and the observation group was given hyperbaric oxygen therapy on the basis of the control group. The clinical efficacy, neurological function, hemodynamics and hemorheology of the two groups were compared. Results The total effective rate in the observation group was apparently higher than that in the control group (P<0.05). After treatment, brain-derived neurotrophic factor (BDNF) level , the mean cerebral vascular velocity (Vmean) and cerebral vascular mean flow (Qmean) of the patients in the two groups were significantly higher, while the levels of dynamic resistance (DR) , peripheral blood flow resistance (R),myelin basic protein (MBP) and neuron-specific enolase (NSE) in the two groups were apparently lower as compared with those before treatment (P<0.05), and the change trend of each index in the observation group was more obvious than that in the control group (P<0.05). After treatment, viscosity high shear, whole blood viscosity low shear, and plasma viscosity were apparently lower than those before treatment (P<0.05), and those indicators in the observation group were apparently lower than those in the control group (P<0.05). Conclusion Hyperbaric oxygen-assisted Naoxintong capsule has a significant effect on HICH patients, which can effectively reduce the degree of neurological impairment, and improve the hemodynamics and hemorheology in the body.