The Expression Levels of Serum IL-1β, TNF-α and IL-6 in Patients with Acute Cerebral Infarction and Their Correlation with the Severity of Cerebral Edema

Abstract

Objective To analyze the expression levels of serum IL-1β, TNF-α and IL-6 in patients with acute cerebral infarction (ACI) and their correlation with the severity of brain edema. Methods A total of 90 ACI patients admitted to our hospital from January 2019 to January 2022 were selected as ACI group, and 60 healthy subjects were selected as healthy control group. The expression levels of interleukin-1 β (IL-1β), tumor necrosis factor-a (TNF-α) and interleukin-6 (IL-6), the disturbance coefficient of cerebral electrical impedance (CEI) on the affected side and the changes of serum factor levels in ACI patients with different degrees of disease were compared between the two groups. The correlation between serum factors and the severity of cerebral edema was analyzed by Pearson correlation method. Results The expression levels of IL-1β, TNF-α and IL-6, and CEI disturbance coefficient in the affected brain of the patients in ACI group were obviously higher than those in the healthy control group (P<0.05). The levels of plasma IL-1β, TNF-α, IL-6 and CEI disturbance coefficient in moderate and severe group were significantly higher than those in mild group (P<0.05). The plasma levels of AIM2, IL-1β and IL-18 in severe group were significantly higher than those in moderate group (P<0.05). In ACI group, the disturbance coefficient of CEI was positively correlated with the levels of serum IL-1β, TNF-α and IL-6 (P<0.05). Conclusion The expression levels of serum IL-1β, TNF-α and IL-6 in ACI patients are positively correlated with the severity of brain edema.