Value Analysis of Shenma Yizhi Recipe in Auxiliary Treatment of Acute Cerebral Infarction Patients with Cognitive Impairment

Abstract

Objective To analyze the value of Shenma Yizhi Recipe in auxiliary treatment of acute cerebral infarction patients with cognitive impairment. Methods From May 2018 to September 2020, 128 patients with acutecerebral infarction and cognitive dysfunction were selected and randomly divided into control group and observation group, with 64 cases in each group. Patients in the control group were given routine symptomatic treatment and citalopram treatment, and those in the observation group were given Shenma Yizhi Recipe on the basis of the control group. Before and after treatment, the neurological function, cognitive function, cerebral blood perfusion parameters, oxidative stress indexes and adverse reactions were compared between the two groups. Results Lower national institutes of health stroke scale (NIHSS) scores, mean transit time (MTT), malondialdehyde (MDA), advanced oxidation protein products (AOPP) and superoxide dismutase (SOD) levels in the two groups after treatment were observed compared to those before treatment (P<0.05), and a lower tendency was shown in the observation group compared to the control group (P<0.05). After treatment, higher scores of montreal cognitive assessment scale (MoCA), mini-mental state examination Scale (MMSE), cerebral blood flow (CBF) and cerebral blood volume (CBV) in the two groups were observed relative to those before treatment (P<0.05), and a lower tendency was shown in observation group compared to the control group (P<0.05). Conclusion Shenma Yizhi Recipe shows high safety in auxiliary treatment of acute cerebral infarction patients with cognitive impairment.