Study on the Effect of Adjuvant Therapy of Shexiang Sihuang Granules on Neurological Function and Coagulation Function in Patients with Acute Cerebral Infarction

Abstract

Objective To explore the effect of adjuvant therapy of Shexiang Sihuang granules on neurological function and coagulation function in patients with acute cerebral infarction (ACI). Methods 126 ACI patients who received treatment in our hospital from March 2019 to March 2022 were randomly divided into a control group and an observation group, with 63 cases in each group. Patients in the control group was treated with alteplase, while those in the observation group were treated with Shexiang Sihuang granules based on the control group. The clinical efficacy, serum factor levels, coagulation function indicator levels and adverse reactions of the two groups were compared. Results The total effective rate of clinical treatment in the observation group was significantly higher than that in the control group (P<0.05); after treatment, the levels of neuron-specific enolase (NSE), central nervous system specific protein (S-100β), and D-dimer (D-D) in the two groups were significantly lower than those before treatment (P<0.05), and these levels in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of nerve growth factor (NGF) and prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT) were obviously higher than before treatment (P<0.05), and the levels in the observation group were evidently higher than those of the control group (P<0.05). The incidence of adverse reactions in the two groups was not statistically significant (P>0.05). Conclusion Adjunctive treatment with Shexiang Sihuang granules can effectively relieve the clinical symptoms of patients with ACI, which is helpful for improving the body's neurological function and coagulation function, and its effect is safe and reliable.