Effect of Xingnaojing Assist Vinpocetine Therapy on Immune Function and Brain Oxygen Metabolism in Elderly Patients with Acute Cerebral Infarction

Abstract

Objective To explore the effect of Xingnaojing assist vinpocetine therapy on immune function and brain oxygen metabolism in elderly patients with acute cerebral infarction (ACI). Methods 124 elderly ACI patients who were treated in our hospital from May 2019 to December 2021 were randomly divided into observation groups and control groups, with 62 cases in each group. Patients in both groups were given conventional treatment, those in the control group were given vinpocetine on this basis, and patients in the observation group were given Xingnaojing injection on the basis of the control group. The national institutes of health stroke scale (NIHSS), activities of daily living (ADL) scores, T lymphocyte subset, vascular endothelial function index, and brain oxygen metabolism index were compared between the two groups. Results After treatment, the ADL scores, T lymphocyte CD₃⁺, CD₄⁺ ratio, serum vascular endothelial growth factor (VEGF) and nitric oxide (NO) in the two groups were significantly higher than those before treatment (P<0.05), and those of the observation group was evidently higher than that in the control group (P<0.05). After treatment, the NIHSS score, T lymphocyte CD₈⁺ ratio, endothelin-1 (ET-1), and arterial venous oxygen content difference (D(a-jv)O₂) and cerebral oxygen extraction rate (ERO₂) were obviously lower than those before treatment (P<0.05), and those of the observation group was markedly lower than those of the control group (P<0.05). Conclusion Elderly patients with ACI treated with Xingnaojing-assisted vinpocetine can effectively improve nerve function and self-care ability, enhance immunity, promote the recovery of vascular endothelial function and improve blood supply to the brain.