Comparison of Clinical Effects of Ginkgolide and Ginkgo Biloba Extract on Acute Cerebral Infarction

Abstract

Objective To compare the clinical effects of ginkgolide and ginkgo biloba extract on acute cerebral infarction. Methods 120 patients with acute cerebral infarction admitted to our hospital from February 2019 to February 2022 were selected and divided into group A and group B by random number table method, with 60 cases in each group. Patients in group A was given ginkgo biloba extract on the basis of routine treatment, while patients in group B was given ginkgolide on the basis of routine treatment. The clinical efficacy, inflammatory factors, coagulation function and hemorheology of the two groups were compared. Results After treatment, the total effective rate of clinical efficacy in group B was higher than that in group A (P<0.05). Compared with before treatment, the levels of monocyte chemoattractant protein-1 (MCP-1) , Matrix metalloproteinase-9 (MMP-9), plasma fibrinogen (FIB), erythrocyte aggregation index, plasma viscosity (PSV), hematocrit (HCT) in the two groups after treatment were significantly declined (P<0.05), and those data mentioned above in observation group were significantly lower than those in control group (P<0.05). Compared with pre-treatment data, the levels of activated partial thromboplastin time (APTT) and prothrombin time (PT) in the two groups after treatment was significantly increased (P<0.05), and the levels of APTT and PT in observation group were obviously higher than those in control group (P<0.05). Conclusion Ginkgolide is effective in treating acute cerebral infarction, effectively improving the level of inflammatory factors and coagulation function, and promoting the recovery of hemorheology.