Correlation Analysis of Cognitive Impairment with Oxidative Stress and Inflammatory Indicators in Elderly Patients with Alzheimer's Disease

Abstract

Objective To analyze the correlation between cognitive impairment with oxidative stress and inflammatory indicators in elderly patients with alzheimer's disease (AD). Methods A total of 45 elderly patients with AD who were admitted to our hospital from May 2018 to September 2020 were recruited to the AD disease group, and another 45 healthy subjects were recruited to the healthy control group during the same period. The Alzheimer’s disease assessment scale-cognitive subscale (ADAS-cog), levels of serum oxidative stress [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px)] and inflammatory indexes [tumor necrosis factor (TNF)-α, interleukin (IL)-8, IL-6] of all the subjects were determined. The Pearson correlation analysis was used to analyze the correlation between cognitive function with oxidative stress and inflammatory indicators in AD group. Results The ADAS-cog score of AD disease group was significantly higher than that of healthy control group (P<0.05); the level of MDA in AD disease group was greatly higher than that in healthy control group (P<0.05), and the levels of SOD and GSH-Px in AD disease group were sharply lower than that in healthy control group (P<0.05). The levels of TNF-α, IL-8 and IL-6 in AD disease group were significantly higher than those in healthy control group (P<0.05). The ADAS-cog score of AD disease group was positively correlated with the levels of serum TNF-α, IL-8, IL-6 and MDA (r=0.407, 0.342, 0.433, 0.440; P<0.05), and was negatively correlated with the levels of SOD and GSH-Px (r=-0.486, -0.434; P<0.05). Conclusion The cognitive function of elderly patients with AD was sharply reduced, and there were relatively serious oxidative stress and inflammatory reactions in the body. In addition, the cognitive function of patients was closely correlated with the oxidative stress and inflammatory indicators.