Effect of Shenzhi Capsules on Oxidative Stress and Neurological Function in Parkinson’s Disease

Xiaoyang Chen; Chenfei Huang

Authors

Xiaoyang Chen Department of Traditional Chinese Medicine, Yongjia County People's Hospital, 325000 Wenzhou, Zhejiang, China Author
Chenfei Huang Department of Rehabilitation and Acupuncture, Yongjia County People's Hospital, 325000 Wenzhou, Zhejiang, China Author

Keywords:

Shenzhi capsules, Donepezil hydrochloride tablets, Parkinson’s disease, Oxidative stress, Neurological function

Abstract

Objective To analyze the effect of Shenzhi capsule adjuvant therapy on oxidative stress and neurological function in patients with Parkinson’s disease (PD). Methods 108 patients with PD in our hospital from January 2018 to August 2020 were selected and randomly divided into the control group (n=54) and the observation group (n=54). The control group was treated with donepezil hydrochloride tablets, and the observation group was treated with Shenzhi capsules on the basis of the control group. The severity of dementia, cognitive impairment and PD, activities of daily living, neurological function and oxidative stress were compared between the two groups. Results After treatment, the score of simple scale mental state examination (MMSE), montreal cognitive assessment scale (MoCA), activity of daily living (ADL) in the two groups were apparently higher than those before treatment (P<0.05). The score of Parkinson’s assessment subscales (UPDR) in the two groups were apparently lower than that before treatment (P<0.05), and the score of MMSE, MoCA, ADL in the observation group were apparently higher than those in the control group (P<0.05). The score of UPDR in the observation group was apparently lower than that in the control group (P<0.05). After treatment, the levels of brain derived neurotrophic factor (BDNF), superoxide dismutase (SOD) in the two groups were apparently higher than those before treatment (P<0.05), and the levels of acid calcium binding protein (S-100β), neuron-specific enolase (NSE), malonic dialdehyde (MDA) were apparently lower than those before treatment (P<0.05). The levels of BDNF, SOD in the observation group were apparently higher than those in the control group (P<0.05), and the levels of S-100β, NSE, MDA in the observation group were apparently lower than those in the control group (P<0.05). Conclusion On the basis of donepezil hydrochloride tablets treatment, Shenzhi capsules adjuvant treatment has a good effect on patients with PD, which could effectively reduce oxidative stress level, improve neurological function, cognitive function, and mental state, and improve their activities of daily living.