Effects of Huanglian Jiedu Decoction Combined with Acarbose on Vascular Endothelial Function in Patients with Type 2 Diabetes Mellitus

Abstract

Objective: To investigate the effects of Huanglian Jiedu Decoction combined with acarbose on vascular endothelial function in patients with type 2 diabetes mellitus (T2DM). Methods: 45 patients with T2DM who were treated with Huanglian Jiedu Decoction combined with acarbose in our hospital from January 2022 to June 2023 were included as the combination group, and 45 patients with T2DM treated with acarbose were enrolled as the control group during the same period. Both groups were treated for 2 months. The clinical efficacy of the two groups was compared. Data of vascular endothelial function index, insulin secretion function index and blood glucose level in the two groups were collected, and the occurrence of adverse reactions in the two groups during treatment was statistically collated. Results: The total effective rate of the combination group was higher than that of the control group (p < 0.05). The levels of endothelin-1 (ET-1), fasting blood glucose, 2 h postprandial blood glucose, glycated hemoglobin, fasting insulin (FINS) and insulin resistance (HOMA-IR) in both groups were decreased after treatment, and these indexes were lower in the combination group than the control group (p < 0.05). The levels of nitric oxide (NO), endothelial nitric oxide synthetase (eNOS) and islet beta cell function index (HOMA-β) in the two groups were increased after treatment, which were higher in the combination group than the control group (p < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (p > 0.05). Conclusion: Huanglian Jiadu Decoction combined with acarbose is effective in the treatment of T2DM, which can improve the endothelial function and insulin secretion function, and effectively control the blood glucose level, without causing serious adverse reactions.