Effect of Dietary Intervention Combined with Anshen Ziyin Xiehuo Prescription on Children with Idiopathic Central Precocious Puberty

Abstract

Objective: This study explores the effect of dietary intervention combined with Anshen Ziyin Xiehuo prescription on children with idiopathic central precocious puberty. Methods: Forty-seven children treated with dietary intervention combined with Anshen Ziyin Xiehuo prescription in our hospital from January 2022 to December 2022 were allocated into dietary group, and 47 children treated with Anshen Ziyin Xiehuo prescription during the same period were assigned into control group. Treatment was performed for 6 months. The clinical effects in the two groups were compared, and the changes of bone age, bone metabolism, breast development, and ovarian function before and after treatment were evaluated and compared. Results: The total effective rate of clinical efficacy in the dietary group was significantly higher than that in the control group (p < 0.05). After treatment, bone age, Tanner breast staging score, and levels of estrogen, luteinizing hormone, and follicle-stimulating hormone in the two groups were decreased, and these in the dietary group were lower than those in the control group (p < 0.05). The levels of total procollagen type I amino-terminal propeptide and beta-C-terminal telopeptide of type I collagen were increased in two groups, and the levels in the dietary group were higher than those in the control group (p < 0.05). During treatment, no adverse reactions such as hyperhidrosis, back pain, dizziness, and dry mouth were found in both groups. Conclusions: Dietary intervention combined with Anshen Ziyin Xiehuo prescription has good clinical efficacy in the treatment of idiopathic central precocious puberty, which can slow down the growth of bone age and inhibit bone metabolism as well as development of breast and ovarian, with good safety.