Clinical Therapeutic Effect of Liuwei Dihuang Decoction Combined with Methimazole on Gestational Hyperthyroidism with Insomnia

Abstract

Objective: Hyperthyroidism is one of the common endocrine disorders in pregnant women during pregnancy, often accompanied by insomnia. The current treatment plan has shortcomings such as long treatment time and significant adverse reactions, and our study aimed to detect the clinical therapeutic effect of Liuwei Dihuang Decoction combined with methimazole on gestational hyperthyroidism with insomnia. Methods: 46 cases of gestational hyperthyroidism with insomnia, who were treated with Liuwei Dihuang Decoction combined with methimazole, were included as the combination group, and 46 cases treated with methimazole were enrolled as the control group. The clinical efficacy and pregnancy outcome were compared between the two groups, and the serum hormone level and Pittsburgh Sleep Quality Index (PSQI) scores of the two groups were collected. Results: The combination group had a higher total effective rate compared to the control group (p < 0.05). After treatment, free triiodothyronine (FT₃) level, free thyroxine (FT₄) level and PSQI score in both groups were decreased, which were lower in the combination group than the control group (p < 0.05). Thyroid stimulating hormone (TSH) level was elevated in both groups, and was higher in the combination group than the control group (p < 0.05). The adverse pregnancy rate in the combination group was lower than that in the control group (p < 0.05). No serious adverse reactions occurred in both groups. Conclusions: Liuwei Dihuang Decoction combined with methimazole is effective in the treatment of gestational hyperthyroidism with insomnia, which can improve thyroid function, sleep quality and pregnancy outcome, and will not cause serious adverse reactions.