Application of Bushen Zhuyun Decoction Combined with Clomiphene Citrate Capsule in Patients with Polycystic Ovary Syndrome

Abstract

Objective: This study investigates the efficacy of Bushen Zhuyun Decoction combined with clomiphene citrate capsule in patients with polycystic ovary syndrome (PCOS). Methods: Forty PCOS patients who received Bushen Zhuyun Decoction combined with clomiphene citrate capsule in our hospital from March 2021 to March 2022 were allocated into observation group, and another 40 PCOS patients who received clomiphene citrate capsule were assigned into control group. The treatment course was limited to 3 menstrual cycles. The clinical efficacy in the two groups of patients was compared, the ovulation and serum sex hormone levels of the patients with different treatment methods were evaluated, and the safety and 1-year efficacy were analyzed. Results: The clinical total effective rate, ovulation rate, and pregnancy rate after 1 year in observation group were higher than those in control group (p < 0.05). After treatment, endometrial thickness and levels of estradiol (E₂) and serum follicle stimulating hormone (FSH) were elevated, but luteinizing hormone (LH) and testosterone (T) levels were reduced in both groups, where the change of these indicators in observation group was greater than that in control group (p < 0.05). There was no significant difference in the occurrence of adverse reactions such as nausea, vomiting, and breast tenderness between the two groups (p > 0.05). Conclusion: Bushen Zhuyun Decoction combined with clomiphene citrate capsule may have a better effect on PCOS patients, which can improve ovulation and sex hormone secretion, with high safety and better 1-year efficacy.