Changes of CAR, IL-28A and CCL28 Levels in COPD Patients with Pulmonary Hypertension and Their Predictive Value

Xiangchao Kong; Hengchao  Zhang

Authors

Xiangchao Kong Department of Cardiology, Deqing Third People's Hospital, 313200 Zhejiang, China Author
Hengchao Zhang Department of Cardiology, Deqing Third People's Hospital, 313200 Zhejiang, China Author

Keywords:

Chronic obstructive pulmonary disease, Pulmonary hypertension, C-reactive protein to albumin ratio, interleukin-28A, C-C motif chemokine ligand 28, predictive value

Abstract

Objective: To explore the changes of C-reactive protein (CRP) to albumin (Alb) ratio (CAR), interleukin-28A (IL-28A) and C-C motif chemokine ligand 28 (CCL28) levels, as well as their predictive value in chronic obstructive pulmonary disease (COPD) patients complicated with pulmonary hypertension (PH). Methods: A total of 110 patients with COPD treated in our hospital from January 2021 to February 2023 were included and divided into COPD combined with PH group (COPD-PH group, n = 54) and COPD combined without PH group (non-COPD PH group, n = 56). Clinical indicators were collected and compared, and serum CAR, IL-28A, and CCL28 levels were contrasted between the two groups. Logistic regression analysis was used to evaluate the risk factors of COPD combined with PH, and the area under curve (AUC) of the receiver operating characteristic (ROC) curve analysis was employed to evaluate the predictive value of serum CAR, IL-28A and CCL28. Results: The levels of CRP, Alb, CAR, IL-28A and CCL28 in COPD-PH group were higher than those in non-COPD-PH group (p < 0.05). CAR, IL-28A and CCL28 were all risk factors for COPD-PH. The AUC values of serum CAR, IL-28A, CCL28 and their combination were 0.930, 0.948, 0.957 and 0.973, respectively (p < 0.05). Conclusion: Serum CAR, IL-28A and CCL28 have predictive value in COPD complicated with PH and are worthy of clinical promotion.

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