Effects of Roxithromycin Combined with Seretide on Pulmonary Function and Inflammatory Factors in Elderly Patients with Severe Stable COPD

Abstract

Objective: To explore the effects of roxithromycin combined with seretide on pulmonary function and inflammatory factors in serum of elderly patients with severe stable chronic obstructive pulmonary disease (COPD). Methods: A total of 100 elderly patients with severe stable COPD were selected from February 2017 to February 2018, and were randomly divided into the control group and observation group, 50 cases in each group. The patients in control group were treated with seretide on the basis of conventional treatment, while those of the observation group were given roxithromycin combined with seretide on the basis of conventional treatment. The clinical efficacy, pulmonary function indicators and inflammatory factors were compared between the two groups before and after treatment. Results: After treatment, the 6-min walk distance in the control group was significantly higher than that before treatment (p < 0.05), the sputum volume and 6-min walk distance in the observation group were significantly higher than those before treatment (p < 0.05). In addition, the sputum volume and 6-min walk distance in the observation group were significantly higher than those in the control group (p < 0.05). After treatment, both FEV1/FVC and FEV1% Pred in the two groups were significantly higher than those before treatment (p < 0.05), and the above pulmonary function indicators in the observation group were significantly higher than those in the control group (p < 0.05). Besides, after treatment, the levels of CRP, IL-8 and TNF-α in the two groups were significantly lower than those before treatment (p < 0.05), and the above inflammatory factors in the observation group were significantly lower than those in the control group (p < 0.05). Conclusion: Roxithromycin combined with seretide in the treatment of elderly patients with severe stable COPD has significant clinical efficacy, can significantly improve the pulmonary function and inflammatory factor levels of patients.