Effects of Theophylline Sustained Release Tablets Combined with Erythromycin on Pulmonary Function and Inflammatory Factors in Elderly Patients with Severe Stable Chronic Obstructive Pulmonary Disease

Abstract

Objective: To investigate the effects of theophylline sustained release tablets combined with erythromycin on pulmonary function and inflammatory factors in elderly patients with severe stable chronic obstructive pulmonary disease (COPD). Methods: A total of 86 elderly patients with severe stable COPD in our hospital were selected from September 2016 to March 2018, and they were randomly divided into control group (n = 43) and observation group (n = 43) according to the random number table method, the control group was treated with erythromycin, the observation group was combined with theophylline sustained release tablets on the basis of the control group, Pulmonary function indexes, levels of inflammatory factors and adverse reactions were compared between the two groups before and after treatment. Results: After treatment, the forced expiratory volume/forced vital capacity in the first second (FEV1/FVC) and the percentage of forced expiratory volume in the first second (FEV1%Pred) of the two groups was significantly higher than those before treatment (p < 0.05), and the level of the above indicators in the observation group was significantly higher than those in the control group (p < 0.05); After treatment, the levels of c-reactive protein (CRP), interleukin (IL)-8 and tumor necrosis factor (TNF)-α in the two groups were significantly lower than those before treatment (p < 0.05), and the level of the above indicators in the observation group was significantly lower than those in the control group (p < 0.05); There was no significant difference in the incidence of adverse reactions between the two groups (p > 0.05). Conclusion: Theophylline sustained release tablet combined with erythromycin has a good effect in treating severe COPD, which can effectively improve lung function and reduce inflammatory factors in elderly patients.