Diagnostic Value of 64-Slice CT Dual Perfusion Parameters Combined with Serum VEGF in Lymph Node Metastasis of Lung Cancer

Abstract

Background: Our study is engineered to explore the diagnostic value of 64-slice computed tomography (CT) dual perfusion parameters combined with serum vascular endothelial growth factor (VEGF) in lymph node metastasis of lung cancer. Methods: The clinical data of 80 patients with suspected lymph node metastasis of lung cancer admitted to our hospital from December 2021 to December 2022 were retrospectively analyzed. According to the pathological examination results, 43 patients with lymph node metastasis of lung cancer were assigned into the metastasis group, and 37 patients with non-metastatic lung cancer lymph nodes were assigned into the non-metastasis group. Blood perfusion parameters and serum VEGF level in the two groups were collected and compared with the results of pathological examination. The diagnostic value of 64-slice CT dual perfusion parameters combined with serum VEGF was analyzed using the area under the receiver operating characteristic (ROC) curves (AUC). Results: In this study, the bronchial arterial blood flow (BAF) and VEGF in metastasis group were significantly higher than those in non-metastasis group (p < 0.05), yet perfusion index (PI) was obviously lower than that in non-metastasis group (p < 0.05). The AUC values of BAF, PI, VEGF and their combination in the diagnosis of lymph node metastasis in lung cancer were 0.809, 0.794, 0.770 and 0.886, respectively. AUC value of combined detection was higher than that of single detection (p < 0.05). Accuracy rates of BAF, PI and VEGF detection were 36.25%, 46.25%, and 30.00%, respectively. BAF and VEGF were positively correlated with lymph node metastasis of lung cancer (p < 0.05), whilst PI was negatively correlated with lymph node metastasis of lung cancer (p < 0.05). Conclusion: 64-slice CT dual perfusion parameters combined with serum VEGF have good diagnostic value for lymph node metastasis of lung cancer. Also, BAF and VEGF may be positively correlated with lymph node metastasis of lung cancer, while PI is negatively correlated with lymph node metastasis of lung cancer.