Analysis of Differential Value of Ultrasonography Assisted with C-TIRADS Classification and Autoantibody and TSH Detection in Benign and Malignant Thyroid Nodules

Abstract

Background: This study analyzes the value of Chinese Thyroid Imaging Report and Data System (C-TIRADS) combined with autoantibodies and TSH-assisted ultrasonography in the differential diagnosis of benign and malignant thyroid nodules. Methods: The clinical data of 106 patients with thyroid nodules treated in our hospital from March 2022 to May 2023 were retrospectively analyzed. C-TIRADS classification, serum thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb), and thyrotropin (TSH) level detection, and elastography examination were performed for all patients, and they were divided into malignant group (n = 44) and benign group (n = 62) according to the pathological diagnosis results of nodular lesions. The positive rate of thyroid nodules diagnosed by the three methods was compared, and the diagnostic efficiency of the three methods was analyzed. Results: According to C-TIRADS classification, the number of patients with category 3 was significantly higher while the number of patients with category 4B and 4C was obviously lower in the benign group compared with those in the malignant group (p < 0.05). The levels of TGAb, TPOAb, and TSH in malignant group were visibly higher than those in benign group (p < 0.05). The proportion of thyroid nodules with ultrasonic elastic score of 2 points in benign group was markedly higher than that in malignant group, while the proportion of thyroid nodules with ultrasonic elastic score of 4 points was significantly lower than that in malignant group (p < 0.05). The positive rates of C-TIRADS, serum TGAb, TPOAb, TSH, and ultrasound elastography in malignant group were strikingly higher than those in benign group (p < 0.05). Compared with the single detection of C-TIRADS classification, serum factors and ultrasound elastography for each individual test, the accuracy, sensitivity and specificity of the three combined detection were significantly higher, and the difference was statistically significant (p < 0.05). Conclusion: C-TIRADS combined with autoantibodies and TSH-assisted ultrasonography has a better effect in the detection of thyroid nodules, which can improve the differential diagnosis of benign and malignant nodules.